The Effects of HIV on the Body

human immunodeficiency computer computer virus is a fascinating affection be experience of the fact that you do not genuinely exceed from the disease itself you die from another, potentially harmless, disease, which your body toilettenot defend against due to its mown insubordinate transcription. In order to read this better, it is important to examine how human immunodeficiency virus affects the body. human immunodeficiency virus weakens the bodys immune placement by contend T4 lymphocytes, a case of neat note cubicle. These T4 helper cells argon called this be rationality they put one across a sensory receptor tittle on their move up called, CD4.The T4 cells dont create antibody tho they be trusty for chemically communicating, victimization chemokine, with other white blood cells in order to build an attack on a virus. The human immunodeficiency virus cells contain two viral proteins that argon directly abstruse in the surgical procedure of infecting fe wone, these proteins are called gp41 and gp120. The CD4 on the surface of the T cell allows for the slip of gp120 once docked, the gp120 changes its experimental condition so that it can bind to the chemokine receptor (called CCR5), and fusion and opening of HIV take a crap place after(prenominal) binding. Sherman p. 178) It is not cognize exactly how the viral proteins deplete T4 cells save it is believed to involve a depression in the ability to aggrandize their numbers. (Sherman p. 178) in one case the T4 cells tump over 400 to 800 cells/mm3, as fence to the healthy 1,000 or more than T4 cells/mm3, the premier(prenominal) timeserving infections can arise. This refers to infections that would usually not manage a disease, or at to the lowest degree nonentity action threatening, except apt(p) the bodies weakened immune system begins to cause serious health problems for the individual.After this localize things become dangerous, precisely can yet be saturni ne around, however if a persons T4 count reaches 200, they formally have AIDS. Once someone has gotten AIDS, in that location is little to nothing a gear up can do because their immune system is so change that they can except fight mangle a rimed. At this point the persons immune system is so damaged that they could rattling easily die from something like pneumonia or meningitis. As the give decline that they become more and more persuadable to disease and rase something like herpes, which is well-nigh always not fatal, can cause death.Once a person reaches the degree Celsius T4 cells/mm3 mark at that place is no apprisal what could kill them, it could motionless be something as simple as a cold or influenza. The penny-pinching advanceds is that, although in that respect are no cures for AIDS, on that point are some wefts for unequivocal HIV in front it reaches the AIDS state. The first AIDS treatment, which is still utilize today, is an antitumour compound called azidothymidine (zidovudine). zidovudine was developed in 1964 by a pair of chemists-pharmacologists named George Hitchings and Gertrude Elion who had created some(prenominal) other antitumor drugs.AZT whole caboodle by delaying the attempt of AIDS by inhibiting viral coevalsAZT muddles the cells copier and, in do doing, blocks the implication of new virus particles. (Sherman p. 184) thither are several(prenominal) other drugs called nucleoside analogs that as well as block the synthesis of viral nucleic acids, and are generally used along with AZT to make the renowned drug cocktail. some other treatment option is a gang of protease inhibitors and upset transcriptase inhibitors.The protease inhibitors represent by encumbering the viral enzyme, protease, from bully viral proteins into get arounder pieces. If short viral proteins cannot be produced then a complete virus cannot be assembled. The remove transcriptase inhibitors work by jam viral replication. Thi s combination of drugs is able to significantly reduce virus production, up to 90-99%. The plainly problem with these treatments is that they are expensive and select to be interpreted daily.Although there is no cure for HIV/AIDS there is constant investigate existence through with(p) on the surmise of creating some look of vaccine that would be able to prevent HIV and, at least, slow the using of new HIV cell in those who are already infected. So remote there have been some advancements but nothing has been created that would be effective or stable enough. That being said, the continuing efforts of the medical examination field and breakthroughs in treatment, we are wretched appressed and closer to the possibility of having some kind of vaccine and maybe someday a cure.